Neurobiology of Disease A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys

Erik K. Kastman,1,2* Auriel A. Willette,2,3,4* Christopher L. Coe,3,4 Barbara B. Bendlin,1,2 Kris J. Kosmatka,1,2 Donald G. McLaren,1,2,5 Guofan Xu,1,2 Elisa Canu,1,2 Aaron S. Field,6 Andrew L. Alexander,4 Mary Lou Voytko,7 T. Mark Beasley,8 Ricki J. Colman,8 Richard H. Weindruch,1,2,9 and Sterling C. Johnson1,2,4,9 1Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, 2Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, 53705, 3Harlow Primate Laboratory, Department of Psychology, University of Wisconsin, Madison, Wisconsin 53715, 4Waisman Imaging Center, University of Wisconsin, Madison, Wisconsin, 53705, 5Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, 6Department of Radiology, University of Wisconsin, Madison, Wisconsin, 53792, 7Department of Neurobiology and Anatomy and Interdisciplinary Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, 8Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, and 9Wisconsin National Primate Research Center, Madison, Wisconsin 53792